Agomir/Antagomir is a chemically modified experimental tool for miRNA functional studies. IntegrateRNA utilizes our cutting-edge technology and state-of-the-art equipment to efficiently synthesize high-quality agomir and antagomir molecules, delivering carefully engineered, synthesized, and purified high-quality sequences to our customers. Our strong portfolio of expertise and technologies also allows us to provide additional services such as base modification, conjugation with various molecules such as fluorescent dyes or nanoparticles for imaging or targeting purposes, and even in vivo delivery of agonists or anti-agonists to study their biological effects.
Introduction of miRNA Agomir/Antagomir
Both miRNA agomir and antagomir are chemically modified microRNA molecules that have a wide range of applications due to their ability to manipulate miRNA expression. miRNA agomirs mimic the function of endogenous miRNAs. They are specially labeled and chemically modified small double-stranded RNA molecules that are complementary to the target miRNA sequence. Upon introduction into cells, agomirs bind to endogenous miRNAs and activate their function, thereby enhancing repression of target genes. miRNA antagomirs are chemically modified single-stranded small RNA molecules, but they are designed to specifically target and inhibit specific endogenous miRNAs based on the miRNA sequence. Antagomirs bind to the target miRNA sequence, preventing it from interacting with the mRNA target, which results in an increase in the expression of the target gene.
Our microRNA Agomir & Antagomir Synthesis Service
IntegrateRNA provides high-quality miRNA agomir/antagomir using our advanced fully automated synthesis and purification equipment, and we offer flexible customization, modification, and quality validation to meet any of our customers' research demands.
Our services mainly include the following:
- Custom miRNA agomir/antagomir synthesis service
IntegrrateRNA provides flexible custom synthesis of miRNA agomir/antagomir by chemical synthesis method. Our scientists provide synthetic design services for specific targets or species and modify and purify them according to customers' research demands. We also utilize advanced miRNA sequencing platforms to fully test and validate the synthesized sequences to ensure the purity and integrity of miRNA agomir/antagomir molecules.
- miRNA agomir/antagomir modifications service
We offer a variety of miRNA modification and labeling services that can modify synthetic miRNA agomir or antagomir to improve their stability or target specificity.